Cayman Eos-D9 (D181-D9320182); Purity- Greater Than Or Equal To 9

Ibudilast is an inhibitor of phosphodiesterase 4 (PDE4; IC₅₀s = 54, 65, 239, and 166 nM for PDE4A-D, respectively). It is selective for PDE4 over PDE1, PDE7A, PDE7B, and PDE9A (IC₅₀s = ≥10,000 nM for all) but does inhibit PDE3A, PDE3B, and PDE5A (IC₅₀s = 1,600, 2,700, and 3,510 nM, respectively). Ibudilast inhibits LPS-induced production of TNF-α and fMLP-induced production of leukotriene B₄ (LTB₄; Item No. ) in isolated human whole blood (IC₅₀s = 6.2 and 2.5 μM, respectively). It inhibits bronchospasm by 34% in a guinea pig model of leukotriene-mediated allergic bronchospasm when administered intravenously at a dose of 5 mg/kg. Ibudilast prevents increases in TNF-α, IL-1β, and IL-6 expression in the striatum in a mouse model of MPTP-induced Parkinsons disease. It also increases striatal expression of glial cell-derived neurotrophic factor (GDNF) in MPTP-treated and -untreated mice when administered at doses of 40 and 50 mg/kg, respectively, twice per day.

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