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Cayman C18 ((В±)-2-Hydroxy) Dihydro Ceramide (D180180); Purity-
NETA PART: | CAYM-24437-5 |
MFG.PART: | 24437-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
ARN14686 is an activity-based affinity probe for the detection of N-acylethanolamine acid amidase (NAAA) using click chemistry. It binds covalently to the N-terminal cysteine of catalytically active NAAA to form a thioester adduct. ARN14686 inhibits the hydrolysis of the NAAA substrate PAMCA in HEK293 cells (IC50s = 6 and 13 nM for human and rat recombinant enzymes, respectively) and is selective for NAAA over acid ceramidase (IC50 = 1,200 nM for the rat enzyme). It labels NAAA in HEK293 cells overexpressing human or rat recombinant NAAA and, when used at concentrations of 1 and 10 µM, in rat lung lysosomal fractions in vitro. It also detects NAAA in lung lysosomal fractions following intravenous administration at a dose of 10 mg/kg in rats. ARN14686 (3 mg/kg) has been used to determine that catalytically active NAAA is present in inflamed rat paw in a complete Freund’s adjuvant model of inflammation.
WARNING This product is not for human or veterinary use.
Technical Information
- Click Tag™ ARN14686
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 1 mg/ml
Shipping & Storage Information
SKU | CAYM-24437-5 |
---|---|
Supplier Part Number | 24437-5 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/24437m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 215528-91-9 |