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Cayman Xl413 (Hydrochloride); Purity- Greater Than Or Equal To 98
NETA PART: | CAYM-24906-25 |
MFG.PART: | 24906-25 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
XL413 is a potent inhibitor of Cdc7 (IC50 = 3.4 nM).1 It is >60, >10, and >300-fold selective for Cdc7 over CK2, PIM1, and a panel of over 100 protein kinases, respectively. XL413 inhibits the growth of MDA-MB-231T and COLO 205 cells (IC50s = 118 and 140 nM, respectively). It inhibits Cdc7-specific phosphorylation of mini-chromosome maintenance protein (MCM2) and induces cell cycle accumulation in the S and G2 phases in MDA-MB-231T and COLO 205 cells that overexpress Cdc7. In vivo, XL413 inhibits MCM2 phosphorylation (ED50 = <3 mg/kg) and reduces tumor growth in a COLO 205 mouse xenograft model when administered orally at doses of 10, 30, and 100 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
- DMSO: 0.2 mg/ml
- PBS (pH 7.2): 10 mg/ml
Shipping & Storage Information
SKU | CAYM-24906-25 |
---|---|
Supplier Part Number | 24906-25 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/24906m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 25 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 2062200-97-7 |