Cayman Marmesin; Purity- Greater Than Or Equal To 98%; Size- 50 M

Marmesin is a coumarin originally isolated from the mature bark of A. marmelos.¹ Marmesin decreases proliferation and cell invasion induced by fetal bovine serum (FBS) in H1299 non-small cell lung cancer cells (NSCLCs) when used at a concentration of 10 µM.² It decreases VEGF secretion in A549 and H1299 cells and inhibits capillary-like structure formation by human umbilical vein endothelial cells (HUVECs). Marmesin also decreases proliferation of U937 human leukemia cells (IC₅₀ = 40 µM).³ It halts the cell cycle at the G₂/M phase, increases the ratio of Bax to Bcl-2 protein, induces apoptosis, and inhibits cell migration. Marmesin reduces tumor growth in a U937 mouse xenograft model when administered at a dose of 30 mg/kg.

WARNING This product is not for human or veterinary use.