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Cayman Alprenolol; Purity- Greater Than Or Equal To 98%; Size- 25
NETA PART: | CAYM-25338-25 |
MFG.PART: | 25338-25 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Alprenolol is a non-selective β-adrenergic receptor (β-AR) antagonist that is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1B.1,2 It binds to β1-, β2-, and β3-ARs expressed in CHO cells (Kds = 15, 0.91, and 117 nM, respectively, for the human receptors) and to 5-HT1A and 5-HT1B receptors in rat hippocampal and striatal membranes (Kis = 34 and 134 nM, respectively).1,2 In vivo, alprenolol (40 mg/kg, i.v.) completely blocks the hyperactivity response of rats to 2-PCPA (Item No. 10010494) and L-tryptophan.3 Alprenolol (10 μg, i.v.) inhibits decreases in heart rate and left ventricular systolic pressure induced by the β2-AR antagonist ICI 118551 (Item No. 15591) in transgenic mice overexpressing the β2-AR.4 It also reduces the level of abnormal prion fibrils (PrPSc) in the brain of mice intracerebrally infected with prion disease to less than 20% of control levels when administered in drinking water at a dose of 50 mg/L.5
WARNING This product is not for human or veterinary use.
Technical Information
- (±)-Alprenolol
- dl-Alprenolol
- (RS)-Alprenolol
- DMF: 20 mg/ml
- DMSO: 15 mg/ml
- Ethanol: 5 mg/ml
- PBS (pH 7.2): 1 mg/ml
Shipping & Storage Information
SKU | CAYM-25338-25 |
---|---|
Supplier Part Number | 25338-25 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/25338m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 25 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 13655-52-2 |