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Cayman Szl P1-41; Purity- Greater Than Or Equal To 98%; Size- 10
NETA PART: | CAYM-26142-10 |
MFG.PART: | 26142-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Grazoprevir is a pan-genotypic protease inhibitor that binds to hepatitis C virus (HCV) non-structural protein 3/4A (NS3/4A), a serine protease essential for viral replication. Grazoprevir has potent in vitro activity against major HCV genotypes (Kis = 0.1, 0.1, 0.08, 0.15, and 0.9 nM for genotypes 1a, 1b, 2a, 2b, and 3a, respectively) and common resistance genotypes (Kis = 0.07, 0.14, and 0.30 nM for genotypes 1b R155K, D165V, and D168Y, respectively). Grazoprevir inhibits the NS3/4A protease in an in vitro replicon system with EC50 values of 2 and 8 nM for genotypes 1a and 2a, respectively. Formulations containing grazoprevir are used in combination therapies to treat HCV.
WARNING This product is not for human or veterinary use.
Technical Information
- MK-5172
- DMF: 30 mg/mL
- DMF:PBS (pH 7.2) (1:4): 0.2 mg/mL
- DMSO: 25 mg/mL
- Ethanol: 15 mg/mL
Shipping & Storage Information
SKU | CAYM-26142-10 |
---|---|
Supplier Part Number | 26142-10 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/26142m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 222716-34-9 |