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Cayman Szl P1-41; Purity- Greater Than Or Equal To 98%; Size- 25
Cayman Szl P1-41; Purity- Greater Than Or Equal To 98%; Size- 25 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$492.00
Your Price
$492.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CAYM-26142-25 |
MFG.PART: | 26142-25 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
SZL P1-41 is an inhibitor of the Skp1-Cullin1-F-box (SCF) family protein Skp2.1 It inhibits the interaction between Skp2 and Skp1 to block Skp2 E3 ubiquitin ligase activity when used at a concentration of 5 μM. SZL P1-41 selectively inhibits Skp2 over Fbw7 and β-TrCP E3 ubiquitin ligase activity in HEK293T cells. It reduces survival of LNCaP and PC3 prostate cancer cells in a concentration-dependent manner via inhibition of aerobic glycolysis and induction of apoptosis. SZL P1-41 (40 and 80 mg/kg) reduces tumor volume in A549 lung cancer and PC3 prostate cancer mouse xenograft models.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-(2-benzo thiazolyl)-6- ethyl-7- hydroxy-8-(1- piperidinyl methyl)-4H-1- benzopyran-4- one
CAS Number
222716-34-9
Molecular Formula
C24H24N2O3S
Formula Weight
420.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 1 mg/ml
- DMSO: 0.3 mg/ml
- Ethanol: 0.3 mg/ml
λmax
224, 264, 308
SMILES
O=C1C(C2=NC3=C(C=CC=C3)S2)=COC4=C1C=C(CC)C(O)=C4CN5CCCCC5
InChi Code
InChI=1S/C24H24N2O3S/c1-2-15-12-16-22(28)18(24-25-19-8-4-5-9-20(19)30-24)14-29-23(16)17(21(15)27)13-26-10-6-3-7-11-26/h4-5,8-9,12,14,27H,2-3,6-7,10-11,13H2,1H3
InChi Key
JKIXLEKBXHMXTN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
SKU | CAYM-26142-25 |
---|---|
Supplier Part Number | 26142-25 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/26142m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 222716-34-9 |