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Cayman 4-Cyano Adb-Butinaca, N-(1-Amino-3,3-Dimethyl-1-Oxobutan-2
Cayman 4-Cyano Adb-Butinaca, N-(1-Amino-3,3-Dimethyl-1-Oxobutan-2-Yl)-1-(4-Cyanobutyl)-1h-Indazole-3-Carboxamide, 1 Mg - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$81.00
Your Price
$81.00
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| NETA PART: | CAYM-26506-1 |
| MFG.PART: | 26506-1 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Lacidipine is a dihydropyridine L-type calcium channel blocker. It induces relaxation of isolated rat aorta and inhibits calcium-induced contraction of rabbit ear artery (pA2 = 9.4). It also induces relaxation of calcium-induced contractions in isolated rat colon and bladder and guinea pig trachea (IC50s = 6.7, 6, and 7.8 nM, respectively). Lacidipine induces negative inotropy in isolated guinea pig ventricular strips (IC50 = 110 nM). It reduces mean blood pressure in spontaneously hypertensive rats (ED25 = 0.35 mg/kg) and in renal hypertensive dogs (ED25 = 0.22 mg/kg) with a transient increase in heart rate. Lacidipine inhibits copper-induced oxidation of isolated human LDL when used at concentrations of 1 and 5 µM. It reduces the extension of aortic atheromatous lesions and decreases renal injury in ApoE-/- mice in a model of Western diet-induced atherosclerosis.
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | 4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester |
| CAS Number | 103890-78-4 |
| Synonyms |
|
| Molecular Formula | C26H33NO6 |
| Formula Weight | 455.5 |
| Purity | ≥98% |
| Formulation | A solid |
| Solubility |
|
| λmax | 240, 284, 368 nm |
| SMILES | CC1=C(C(OCC)=O)C(C2=C(/C=C/C(OC(C)(C)C)=O)C=CC=C2)C(C(OCC)=O)=C(C)N1 |
| InChi Code | InChI=1S/C26H33NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15,23,27H,8-9H2,1-7H3/b15-14+ |
| InChi Key | GKQPCPXONLDCMU-CCEZHUSRSA-N |
| Storage | -20°C |
| Shipping | Room Temperature in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-26506-1 |
|---|---|
| Supplier Part Number | 26506-1 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/26506m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |