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Cayman 1,3-Dipalmitoyl-Rac-Glycerol; Purity- Greater Than Or Equa
NETA PART: | CAYM-26974-1 |
MFG.PART: | 26974-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Tetrahydrocurcumin is a metabolite of curcumin (Item Nos. | ) that has diverse biological activities, including antioxidant, anti-inflammatory, anti-angiogenic, and anticancer properties.,,, It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. ) radicals in a cell-free assay with an EC50 value of 16.8 μM. Tetrahydrocurcumin (50 µM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) and COX-2 expression in RAW 264.7 cells. It also inhibits LPS-induced increases in TNF-α release when used at a concentration of 100 µM and increases in nitric oxide (NO) production and IL-6 levels in a concentration-dependent manner. Tetrahydrocurcumin reduces carrageenan-induced paw edema in rats (ED50 = 20 mg/kg). It also reduces the formation of neocapillaries and decreases microvascular density as well as VEGF, VEGF receptor 2 (VEGFR2), and hypoxia-inducible factor-1α (HIF-1α) expression in a CaSki cervical cancer nude mouse xenograft model when administered at doses of 100, 300, and 500 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
- NSC 687845
- DMF: 10 mg/ml
- DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml
- DMSO: 5 mg/ml
- Ethanol: 0.25 mg/ml
Shipping & Storage Information
SKU | CAYM-26974-1 |
---|---|
Supplier Part Number | 26974-1 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/26974m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 502-52-3 |