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Cayman Malformin A; Purity- Greater Than Or Equal To 95%; Size- 5
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NETA PART: | CAYM-27510-5 |
MFG.PART: | 27510-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Gliquidone is a second generation sulfonylurea that selectively inhibits ATP-sensitive potassium channel currents (IKATP) in pancreatic β-cells (IC50s = 0.45, 119.1, and 149.7 µM for HIT-T15 cells, cardiomyocytes, and vascular smooth muscle cells, respectively). It is also a peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 10 μM in a transactivation assay). Gliquidone (0.2 nmol/g) decreases plasma levels of D-glucose and stimulates insulin release in anesthetized rats. It decreases blood glucose levels, serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activities, and hepatic lipid peroxidation and increases hepatic glutathione (GSH) levels in a rat model of diabetes induced by streptozotocin (STZ; Item No. ) when administered at a dose of 10 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name | N-[(cyclohexylamino)carbonyl]-4-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinolinyl)ethyl]-benzenesulfonamide |
CAS Number | 33342-05-1 |
Synonyms |
|
Molecular Formula | C27H33N3O6S |
Formula Weight | 527.6 |
Purity | ≥98% |
Formulation | A crystalline solid |
Solubility |
|
λmax | 224 nm |
SMILES | O=C(N1CCC2=CC=C(S(NC(NC3CCCCC3)=O)(=O)=O)C=C2)C4=CC(OC)=CC=C4C(C)(C)C1=O |
InChi Code | InChI=1S/C27H33N3O6S/c1-27(2)23-14-11-20(36-3)17-22(23)24(31)30(25(27)32)16-15-18-9-12-21(13-10-18)37(34,35)29-26(33)28-19-7-5-4-6-8-19/h9-14,17,19H,4-8,15-16H2,1-3H3,(H2,28,29,33) |
InChi Key | LLJFMFZYVVLQKT-UHFFFAOYSA-N |
Storage | -20°C |
Shipping | Room Temperature in continental US; may vary elsewhere |
Stability | ≥ 4 years |
SKU | CAYM-27510-5 |
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Supplier Part Number | 27510-5 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/27510m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | JP |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 3022-92-2 |