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Cayman Gentisic Acid; Purity- Greater Than Or Equal To 98%; Size-
NETA PART: | CAYM-27615-50 |
MFG.PART: | 27615-50 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Gentisic acid is a benzoic acid that has been found in Gentiana and an active metabolite of aspirin (Item No. 70260) with diverse biological activities.1,2,3,4,5 It decreases radiation-induced production of thiobarbituric acid reactive substances (TBARS), hydrogen peroxide, and protein carbonyls, increases superoxide dismutase activity, and prevents hemolysis in isolated human erythrocytes when used at concentrations ranging from 5 to 100 μM.1 Gentisic acid (1-10 μM) inhibits LDL oxidation and formation of cholesterol ester hydroperoxides in isolated human plasma.2 It induces relaxation of isolated guinea pig trachea (EC50 = 20 μM), an effect that is reduced by the large-conductance calcium-activated potassium channel blocker charybdotoxin (Item No. 24115).3 Gentisic acid (10 and 100 mg/kg) reduces cardiac hypertrophy and fibrosis and pulmonary remodeling, suppresses the renin-angiotensin-aldosterone system, and inhibits cardiac dysfunction in a mouse model of transverse aortic constriction-induced cardiac hypertrophy.4 It also prevents cardiovascular collapse and lactic acidemia in a canine model of P. aeruginosa-induced septic shock.5
WARNING This product is not for human or veterinary use.
Technical Information
- Carboxyhydroquinone
- 5-Hydroxysalicylic Acid
- NSC 27224
- NSC 49098
- NSC 78825
- DMF: 2mg/mL
- DMSO: 3mg/mL
- Ethanol: 10mg/mL
- PBS (pH 7.2): 2mg/mL
Shipping & Storage Information
SKU | CAYM-27615-50 |
---|---|
Supplier Part Number | 27615-50 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/27615m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 490-79-9 |