Cayman Resorufin Betad-Galactopyranoside; Purity- Greater Than

LPA₁ (also known as EDG-2) is one of four known LPA receptors (LPA_1-4). LPA_1-3 are part a family of G protein-coupled receptors that share identity to the sphingosine-1-phosphate receptors (S1P_1-5). LPA₁ couples with three types of G proteins, G_i/o, G_q, and G_12/13 to induce a range of cellular responses including activation of phospholipase C, multiple kinases, the serum response element and cell proliferation.^, LPA₁ mRNA is detected a wide range of tissues and cells including brain, heart, small intestine, spleen, testis, kidney, HeLa cells, and A549 cells.^, Mouse and human LPA₁ have 364 amino acids with an estimated molecular weight of 41 kDa. Cayman’s LPA₁ Polyclonal Antibody detects the protein from several species from 43-50 kDa, suggesting heterogeneous LPA₁ post-translational modifications in distinct cells.

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