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Cayman Astilbin; Purity- Greater Than Or Equal To 98%; Size- 5 Mg
NETA PART: | CAYM-28267-5 |
MFG.PART: | 28267-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Astilbin is a flavonoid that has been found in S. glabra and has diverse biological activities.1,2,3 It inhibits cisplatin-induced increases in apoptosis and accumulation of reactive oxygen species (ROS) in HEK293 cells when used at a concentration of 200 μM.1 Astilbin (50 mg/kg) increases renal glutathione (GSH) levels and superoxide dismutase (SOD) and catalase activity and reduces serum creatinine and blood urea nitrogen (BUN) levels, renal IL-1β, IL-6, and TNF-α levels, apoptosis in kidney tissue, and kidney injury in a mouse model of cisplatin-induced nephrotoxicity. It reduces loss of dopaminergic neurons in the substantia nigra and increases striatal GSH levels and SOD activity in a mouse model of MPTP-induced Parkinsons disease when administered at a dose of 50 mg/kg per day.2 Astilbin also reduces descent time in a pole test and increases traction test score in a mouse model of Parkinsons disease, indicating reduced motor deficits. It reduces cell viability of MDA-MB-231 and MCF-7 cells (IC50s = 167.9 and 191.6 μM, respectively), as well as inhibits migration and increases apoptosis when used at concentrations of 50 and 200 μM.3 Astilbin (20 mg/kg every other day for 14 days) reduces tumor growth in an MCF-7 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
- Taxifolin 3-O-rhamnoside
- DMF: 10 mg/ml
- DMSO: 10 mg/ml
- DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml
- Ethanol: 1 mg/ml
Shipping & Storage Information
SKU | CAYM-28267-5 |
---|---|
Supplier Part Number | 28267-5 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/28267m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 29838-67-3 |