Cayman Atreleuton; Qty- 10; Size-10 Mg

Metoprolol-d₆ is intended for use as an internal standard for the quantification of metoprolol (Item No. ) by GC- or LC-MS. Metoprolol is a β₁-adrenergic receptor (β₁-AR) antagonist (K_i = 47 nM in CHO cells expressing the human receptor). It is selective for β₁- over β₂- and β₃-ARs (K_is = 2,730 and >10,000 nM, respectively, in CHO cells expressing the human receptors). Metoprolol (4.7 µM) reduces GTP-induced adenylyl cyclase (AC) activity in CHO cells expressing β₁- and β₂-ARs. It reduces pulse rate in isolated rat atria in a concentration-dependent manner. Metoprolol (10 mg/kg) reduces increased heart rate and mean arterial pressure (MAP) in a rat model of systolic hypertension induced by a fructose-rich diet. Formulations containing metoprolol have been used in the treatment of exercised-induced hypertension, angina, and tachycardia.

WARNING This product is not for human or veterinary use.