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Cayman Pf-05105679, 3-[[[(1r)-1-(4-Fluorophenyl)Ethyl](3-Quinolin
Cayman Pf-05105679, 3-[[[(1r)-1-(4-Fluorophenyl)Ethyl](3-Quinolinylcarbonyl)Amino]Methyl]-Benzoic Acid, 1 Mg - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$32.00
Your Price
$32.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-29489-1 |
| MFG.PART: | 29489-1 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
PF-05105679 is an antagonist of transient receptor potential melastatin 8 (TRPM8; IC50 = 103 nM for inhibition of voltage-activated currents in HEK293 cells expressing the human receptor).1 It is greater than 100-fold selective for TRPM8 over a panel of 90 receptors, ion channels, and enzymes. PF-05105679 inhibits calcium flux induced by cold or the TRPM8 agonist WS-12 in HEK293 cells expressing the human TRPM8 (IC50s = 480 and 181 nM, respectively). Intravenous infusion of PF-05105679 (46.67 μg/kg per minute) reverses cold-induced reductions in bladder capacity in anesthetized guinea pigs. It decreases the core body temperature in rats when administered at doses of 100 and 300 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-[[[(1R)-1-
CAS Number
1398583-31-7
Molecular Formula
C26H21FN2O3
Formula Weight
428.5
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMSO: 10 mg/ml
λmax
232 nm
SMILES
O=C(N([C@@H](C1=CC=C(F)C=C1)C)CC2=CC=CC(C(O)=O)=C2)C3=CC4=C(C=CC=C4)N=C3
InChi Code
InChI=1S/C26H21FN2O3/c1-17(19-9-11-23(27)12-10-19)29(16-18-5-4-7-21(13-18)26(31)32)25(30)22-14-20-6-2-3-8-24(20)28-15-22/h2-15,17H,16H2,1H3,(H,31,32)/t17-/m1/s1
InChi Key
BXNMZRPTQFVRFA-QGZVFWFLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-29489-1 |
|---|---|
| Supplier Part Number | 29489-1 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/29489m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 1398583-31-7 |