Cayman Cgp 60474, 3-[[4-[2-[(3-Chlorophenyl)Amino]-4-Pyrimidinyl]

BMS 687453 is a potent agonist of peroxisome proliferator-activated receptor α (PPARα; EC₅₀ = 10 nM in a transactivation assay using HEK293 cells). It is selective for PPARα over PPARγ (EC₅₀ = 4,100 nM) as well as over a panel of human nuclear hormone receptors, including PPARδ, LXR, and RXR (EC₅₀s = >25 μM). BMS 687453 (10-100 mg/kg) reduces plasma triglyceride levels and increases HDL levels in human ApoA1 transgenic mice. It also reduces serum triglyceride and LDL levels in hamsters fed a high-fat diet.

WARNING This product is not for human or veterinary use.