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Cayman Isorhynchophylline
Cayman Isorhynchophylline - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$89.00
Your Price
$89.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-29650-10 |
| MFG.PART: | 29650-10 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Isorhynchophylline is an oxindole alkaloid that has been found in Uncaria and has diverse biological activities, including neuroprotective, anticancer, and antihypertensive properties.,,, It inhibits decreases in cell viability and increases in intracellular levels of reactive oxygen species (ROS) and malondialdehyde (MDA) induced by amyloid-β (25-35) (Aβ (25-35); Item No. ) in PC12 cells in a concentration-dependent manner. Isorhynchophylline (30 and 100 μM) attenuates decreases in population spike amplitudes in the CA1 region of a rat hippocampal slice model of ischemia induced by oxygen and D-glucose deprivation. It decreases the viability of HepG2, A549, BxPC-3, Caki-1, RPMI-8226, and 786-O cells (IC50s = 130-292 μM). In HepG2 cells, isorhynchophylline induces apoptosis, inhibits cell migration in a wound healing assay, and decreases invasion in a Matrigel™ assay. Isorhynchophylline (0.1% in the diet) decreases right ventricular end systolic pressure, hypertrophy, and fibrosis in a rat model of pulmonary arterial hypertension induced by monocrotaline (Item No. ).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(αE,1′S,6′R,
CAS Number
6859-01-4
Synonyms
- (+)-Isorhynchophylline
Molecular Formula
C22H28N2O4
Formula Weight
384.5
Purity
≥95%
Formulation
A solid
Solubility
- DMF: 10 mg/ml
- DMSO: 10 mg/ml
- DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml
- Ethanol: 1 mg/ml
λmax
242 nm
SMILES
O=C(OC)/C([C@@H]1[C@@H](CC)CN2[C@@]([C@@]3(C(C=CC=C4)=C4NC3=O)CC2)([H])C1)=C/OC
InChi Code
InChI=1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22-/m0/s1
InChi Key
DAXYUDFNWXHGBE-VKCGGMIFSA-N
Origin
Plant/Uncaria rhynchophylla
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-29650-10 |
|---|---|
| Supplier Part Number | 29650-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/29650m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | CN |
| ProductLine | CAYM |
| Qty | 10 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | Y |
| CAS Number | 1811243 |