Cayman Ac480

L-Buthionine-(S,R)-sulfoximine is an irreversible inhibitor of γ-glutamylcysteine synthetase (K_i = 25 µM). It inhibits the proliferation of ZAZ and M14 melanoma cells, as well as A2780 ovarian and MCF-7 breast cancer cells (IC₅₀s = 4.9, 18, 8.5, and 26.5 µM, respectively). L-Buthionine-(S,R)-sulfoximine (100µM) induces ferroptosis in A172 and T98G glioblastoma cells. It increases reactive oxygen species (ROS) levels in HeLa cells when used at a concentration of 10 µM. L-Buthionine-(S,R)-sulfoximine (1 mM), in combination with methylglyoxal, induces apoptosis of bovine aortic endothelial cells (BAECs). It increases the number of eye spots in the retinal pigment epithelium, an indicator of DNA deletions, in mouse pups when administered to pregnant dams at concentrations of 2 and 20 mM in the drinking water. L-Buthionine-(S,R)-sulfoximine decreases cysteine and glutathione (GSH) levels in fetal mice when administered to pregnant dams.

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