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Cayman [Sar9, Met(O2)11]-Substance P (Trifluoroacetate Salt), (S)
Cayman [Sar9, Met(O2)11]-Substance P (Trifluoroacetate Salt), (S)-2-((S)-1-(L-Arginyl-L-Prolyl-L-Lysyl)Pyrrolidine-2-Carboxamido)-N1-((S)-5-Amino-1-(((S)-1-(((S)-1-((2-(((S)-1-(((S)-1-Amino- - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$134.00
Your Price
$134.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-30106-1 |
| MFG.PART: | 30106-1 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
[Sar9, Met(O2)11]-Substance P (Sar-SP) is a peptide agonist of the neurokinin-1 (NK1) receptor. It is selective for NK1 over NK2 and NK3 receptors. Sar-SP induces inositol phosphate formation in U373MG glioblastoma cells with an EC50 value of 3.8 nM, an effect that can be blocked by the NK1 receptor antagonist SR 140333. It induces contractions in isolated human bronchi when used at concentrations of 3, 100, and 1,000 nM. Sar-SP (10, 25, 65, and 100 pmol/animal, i.c.v.) increases mean arterial pressure and heart rate in conscious rats.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(S)-2-((S)-1-
Synonyms
- Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-{Sar}-Leu-Met[O2]-NH2
Molecular Formula
C64H100N18O15S • XCF3COOH
Formula Weight
1393.7
Purity
≥95%
Formulation
A solid
Solubility
- Water: 1 mg/ml
SMILES
O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N(C)CC(N[C@@H](CC(C)C)C(N[C@@H](CCS(C)(=O)=O)C(N)=O)=O)=O)=O)=O)=O)=O)[C@H]3N(C([C@@H](NC([C@H]4N(C([C@@H](N)CCCNC(N)=N)=O)CCC4)=O)CCCCN)=O)CCC3.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C64H100N18O15S.C2HF3O2/c1-38(2)34-46(57(89)74-42(54(69)86)28-33-98(4,96)97)73-53(85)37-80(3)62(94)48(36-40-18-9-6-10-19-40)79-58(90)47(35-39-16-7-5-8-17-39)78-56(88)43(24-26-51(67)83)75-55(87)44(25-27-52(68)84)76-59(91)50-23-15-32-82(50)63(95)45(21-11-12-29-65)77-60(92)49-22-14-31-81(49)61(93)41(66)20-13-30-72-64(70)71;3-2(4,5)1(6)7/h5-10,16-19,38,41-50H,11-15,20-37,65-66H2,1-4H3,(H2,67,83)(H2,68,84)(H2,69,86)(H,73,85)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,88)(H,79,90)(H4,70,71,72);(H,6,7)/t41-,42-,43-,44-,45-,46-,47-,48-,49-,50-;/m0./s1
InChi Key
VDZDOTCGVUBCPG-LYQMAKBCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-30106-1 |
|---|---|
| Supplier Part Number | 30106-1 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/30106m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |