Cayman Oxaloacetic Acid, 2-Oxo-Butanedioic Acid, 50 G

Each vial contains 200 µg of lyophilized peptide consisting of human hepsin amino acids 241-260 (GGYLPFRDPNSEENSNDIAL). This peptide can be used in conjunction with Cayman’s hepsin polyclonal antibody - affinity-purified (aa 2416-260) (Item No. ) to block protein-antibody complex formation during analysis for hepsin. Hepsin is a type II membrane-associated protein that has a extracellular proteolytic domain and exhibits low sequence homology to other known proteases.^, Recently, hepsin overexpression was observed in prostate, breast, kidney, and ovarian cancers and due to low homology to other known proteases may provide a unique target for pharmacological therapy.^,,,, Hepsin is necessary for cell growth in vitro and may play a role in metastatic expansion by factor VII activation.^, The observed molecular mass of hepsin by immunoblotting is 45.3 kDa. Cloning and characterization of murine and rat hepsin indicate 88% overall homology with human hepsin.^,, Northern blotting reveals high levels of hepsin transcripts in liver.^,

WARNING This product is not for human or veterinary use.