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Cayman Olutasidenib, 5-[[(1s)-1-(6-Chloro-1,2-Dihydro-2-Oxo-3-Qui
NETA PART: | CAYM-30370-10 |
MFG.PART: | 30370-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Olutasidenib is an inhibitor of mutant isocitrate dehydrogenase 1 (IDH1; IC50s = 0.021 and 0.114 µM for IDH1R132H and IDH1R132C, respectively).1 It is selective for mutant IDH1 over wild-type IDH1 and mutant IDH2 (IC50s = 22.4, 27.3, and >100 μM for wild-type IDH1, IDH2R172K, and IDH2R140Q, respectively). Olutasidenib inhibits production of ɑ-hydroxyglutaric acid (2-HG; Item Nos. 25894 | 16374) in U87 cells expressing mutant IDH1R132H, IDH1R132C, IDH1R132L, IDH1R132G, and IDH1R132S with IC50 values of 0.009, 0.039, 0.042, 0.006, and 0.009 µM, respectively. It reduces intratumor 2-HG levels in HCT116-IDH1R132H and HCT116-IDH1R132C mouse xenograft models when administered at doses of 12.5, 25, and 50 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
- FT-2102
- DMSO: soluble
Shipping & Storage Information
SKU | CAYM-30370-10 |
---|---|
Supplier Part Number | 30370-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/30370m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 1887014-12-1 |