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Cayman Laminin (925-933), L-Cysteinyl-L-?-Aspartyl-L-Prolylglycyl
NETA PART: | CAYM-31141-5 |
MFG.PART: | 31141-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Tanshinone I is a diterpene that has been found in S. miltiorrhiza and has diverse biological activities, including anticancer, antidiabetic, and neuroprotective properties.,,, It inhibits proliferation in a variety of cancer cell lines, including KB/VCR, MCF-7/ADR, and K562/A02 multidrug resistance cell lines. It inhibits topoisomerase I- and topoisomerase II-mediated supercoiled DNA relaxation activity when used at concentrations of 200 and 25 µM, respectively. Tanshinone I also inhibits proliferation of H358-IR and H157-IR radioresistant lung cancer cells (IC50s = 10.87 and 6.1 µM, respectively) and sensitizes them to radiation. It reduces plasma levels of total cholesterol, triglycerides, LDL, and nonesterified fatty acids and decreases blood glucose levels in a rat model of type 2 diabetes induced by streptozotocin (Item No. ) and a high-fat diet. Tanshinone I reduces the LPS-induced expression of TNF-α, IL-1β, and IL-6 in microglia in vitro. It is neuroprotective in a mouse model of Parkinson’s disease induced by MPTP, preventing dopaminergic cell death in the striatum and improving motor function when administered at a dose of 10 mg/kg per day for two weeks.
WARNING This product is not for human or veterinary use.
Technical Information
- Tanshinone A
- DMF: 1 mg/ml
- DMSO: 0.3 mg/ml
- Ethanol: 0.1 mg/ml
Shipping & Storage Information
SKU | CAYM-31141-5 |
---|---|
Supplier Part Number | 31141-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/31141m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 110590-60-8 |