Cayman L-Homoserine Lactone (Hydrochloride), (3s)-3-Aminodihydro-

CP 154,526 is an antagonist of corticotropin-releasing factor receptor 1 (CRF₁; K_i = 2.7 nM).^, It is selective for CRF₁ over CRF₂ (K_i = >10 μM). CP 154,526 inhibits CRF-induced increases in adrenocorticotropic hormone (ACTH) levels in rat plasma with an ID₅₀ value of 10 mg/kg. It increases the time spent in the open arms of the elevated plus maze in rats when administered at a dose of 1 mg/kg. CP 154,526 (10 mg/kg, twice per day for 14 days) decreases immobility time in the forced swim test in a rat model of depressive-like behavior. It also decreases stress-induced reinstatement of cocaine or heroin self-administration in cocaine- and heroin-trained rats, respectively, when administered at doses of 15 and 30 mg/kg.

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