Cayman Alyssin, 1-Isothiocyanato-5-(Methylsulfinyl)-Pentane, 5 Mg

Alyssin is an isothiocyanate that has been found in W. japonica and has diverse biological activities, including antibacterial, CYP inhibitory, and antiproliferative properties.^1,2,3 It is active against the bacteria B. subtilis, methicillin-sensitive S. aureus, methicillin-resistant S. aureus (MRSA), and E. coli.¹ Alyssin (0.5-2.5 µM) directly inhibits activity of the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 induced by the polycyclic aromatic hydrocarbons (PAHs) anthracene and dibenzo[a,h]anthracene in MCF-7 breast cancer cells.² It inhibits proliferation of HCT116 colon cancer cells (IC₅₀ = <4 µM).³ Alyssin also inhibits platelet aggregation induced by ADP or arachidonic acid (IC₅₀s = 168 and 20 µM, respectively).⁴

WARNING This product is not for human or veterinary use.