Cayman Labetalol-D5 (Hydrochloride), 2-Hydroxy-5-(1-Hydroxy-2-((4

AS-19 is an agonist of the serotonin (5-HT) receptor subtype 5-HT₇ (K_i = 0.6 nM). It is selective for 5-HT₇ over 5-HT_1A, 5-HT_1B, 5-HT_1D, and 5-HT_5A receptors (K_is = 89.7, 490, 6.6 and 98.5 nM, respectively), as well as sigma-1 and imidazoline I₂ receptors (K_is = 657 and 282 nM, respectively). AS-19 increases conditioned responses and reverses amnesia induced by the muscarinic acetylcholine receptor antagonist scopolamine in rats in an autoshaping learning task when administered post-training at a dose of 5 mg/kg. It increases the paw withdrawal threshold in a mechanical pressure test in rats with chronic constriction injury when 0.3 µl of a 1.5 nM solution is injected into the ventrolateral periaqueductal gray area (vlPAG), an effect that can be blocked by the 5-HT₇ receptor antagonist SB-269970 (Item No. ).

WARNING This product is not for human or veterinary use.