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Cayman D-Pyroaspartic Acid, 4-Oxo-2r-Azetidinecarboxylic Acid, 50
Cayman D-Pyroaspartic Acid, 4-Oxo-2r-Azetidinecarboxylic Acid, 500 Mg - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$601.00
Your Price
$601.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CAYM-31696-500 |
MFG.PART: | 31696-500 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
RTA 408 is a synthetic triterpenoid that binds Keap1 and attenuates the degradation of Nrf2 at concentrations ≤25 nM. In this way, it suppresses the generation of nitric oxide and pro-inflammatory cytokines in macrophages stimulated with IFN-γ. At higher concentrations, RTA 408 inhibits tumor cell growth (GI50 = 260 nM), blocks NF-κB signaling, and decreases levels of cyclin D1. Topical application of RTA 408 activates Nrf2 and provides cytoprotective effects.,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-(2-cyano-3,12- dioxo-28-noroleana- 1,9(11)-dien-17-yl)-2,2- difluoro-propanamide
CAS Number
1474034-05-3
Synonyms
- Omaveloxolone
Molecular Formula
C33H44F2N2O3
Formula Weight
554.7
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 2 mg/ml
- DMSO: 2 mg/ml
- Ethanol: 2 mg/ml
- Ethanol:PBS (pH 7.2)(1:2): 0.25 mg/ml
λmax
239 nm
SMILES
O=C1[C@@]2([H])[C@](CC[C@]3(NC(C(F)(F)C)=O)[C@@]2([H])CC(C)(C)CC3)(C)[C@]4(C)CC[C@@]5([H])C(C)(C)C(C(C#N)=C[C@]5(C)C4=C1)=O
InChi Code
InChI=1S/C33H44F2N2O3/c1-27(2)11-13-33(37-26(40)32(8,34)35)14-12-31(7)24(20(33)17-27)21(38)15-23-29(5)16-19(18-36)25(39)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3,(H,37,40)/t20-,22-,24-,29-,30+,31+,33-/m0/s1
InChi Key
RJCWBNBKOKFWNY-IDPLTSGASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
SKU | CAYM-31696-500 |
---|---|
Supplier Part Number | 31696-500 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/31696m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 62860-12-2 |