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Cayman Follistatin (Human, Recombinant); Size- 50 Micrograms
![](https://netam2po.netascientific.info/media/skin/seal2.png)
![](https://netam2po.netascientific.info/media/skin/seal.png)
NETA PART: | CAYM-31839-50 |
MFG.PART: | 31839-50 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Follistatin is a glycoprotein with roles in the reproductive system, as well as during development and in cell growth and differentiation., It is composed of an N-terminal region, three 10-cysteine follistatin domains (FSDs), and a C-terminal segment. Alternative splicing of FST, the gene encoding follistatin, generates two isoforms: FS-288 and FS-315, which differ in the length of the C-terminal region, and a third isoform, FS-303, is formed through proteolytic cleavage of FS-315.,, Follistatin is ubiquitously expressed and primarily secreted but is found in the cytosol of certain cells., It binds to proteins in the TGF-β superfamily, including activin, inhibin, and myostatin, and prevents them from interacting with their respective receptors. This inhibition of TGF-β family proteins leads to a wide variety of effects on inflammation, immunity, muscle formation, and cancer, among others.,, Overexpression of FST in breast cancer cells in vitro reduces cell growth rate, and FST expression in breast cancer is associated with increased relapse-free survival. FST gene therapy increases muscle mass and reduces knee inflammation in a mouse model of high-fat diet-induced obesity and surgically induced osteoarthritis. Cayman’s Follistatin (human, recombinant) protein can be used for ELISA and binding assay applications. This protein is a disulfide-linked homodimer. The reduced monomer, composed of follistatin (amino acids 30-344) fused to human IgG1 Fc at its C-terminus, consists of 556 amino acids and has a calculated molecular weight of 61.7 kDa. As a result of glycosylation, the monomer migrates at approximately 70 kDa by SDS-PAGE under reducing conditions.
WARNING This product is not for human or veterinary use.
Technical Information
- Activin-binding Protein
- FS
- FSH-suppressing Protein
- FST
Shipping & Storage Information
SKU | CAYM-31839-50 |
---|---|
Supplier Part Number | 31839-50 |
UM | UN |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/31839m.pdf |
Temperature | -80 |
Refrigerated-Frozen | Frozen |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 50 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |