Cayman Cytokeratin 14 (C-Term) Rabbit Monoclonal Antibody, 100

Cytokeratin 14 (CK-14) is a type I acidic epithelial intermediate filament protein. It is composed of a central rod containing four α-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively.^, CK-14 is expressed in stratified squamous epithelial cells, keratinocytes, and myoepithelial cells in the basal layer of the epidermis and is an integral component of the epithelial cell cytoskeleton.^,, It dimerizes with the type II basic epithelial intermediate filament protein CK-5 via heptad repeats in the central rod domain to form a network of filament bundles throughout the cytoplasm.^, Increased tumor levels of CK-14 have been found in patients with squamous cell carcinomas of the bladder, lung, or cervix. Mutations in the gene encoding CK-14 have been found in patients with epidermolysis bullosa simplex (EBS), a disorder characterized by skin blistering. Caymans Cytokeratin 14 (C-Term) Rabbit Monoclonal Antibody (Clone RM328) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

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