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Cayman Tak-981; Size- 10 Mg
Cayman Tak-981; Size- 10 Mg - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$469.00
Your Price
$469.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-32741-10 |
| MFG.PART: | 32741-10 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Hederagenin is a triterpene saponin that has been found in P. eximia with diverse biological activities.,,,, It increases production of reactive oxygen species (ROS), reduces colony formation, and induces apoptosis in cisplatin-resistant head and neck carcinoma (HNC) cells. In vivo, hederagenin (50, 100, and 200 mg/kg) suppresses tumor growth in a cisplatin-resistant HNC mouse xenograft model. It reduces aortic atherosclerotic lesion area, serum cholesterol and LDL levels, and inducible nitric oxide synthase (iNOS) protein levels in a rat model of atherosclerosis. Hederagenin (50 mg/kg) reduces ethanol-induced production of TNF-α, IL-6, and COX-2, alcohol dehydrogenase 2 (ALDH2) mRNA expression, and liver damage in a rat model of alcohol-induced hepatotoxicity. It also induces autophagy and inhibits oligomerization of α-synuclein in a mouse model of Parkinsons disease induced by MPTP.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(4α)-3β,23-
CAS Number
465-99-6
Synonyms
- Astrantiagenin E
- Caulosapogenin
- Hederagenic Acid
- NSC 24954
Molecular Formula
C30H48O4
Formula Weight
472.7
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 30 mg/ml
- Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
SMILES
O[C@H]1CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])CC(C)(C)CC[C@]5(C(O)=O)CC[C@@]4(C)[C@]3(C)CC[C@@]2([H])[C@]1(C)CO
InChi Code
InChI=1S/C30H48O4/c1-25(2)13-15-30(24(33)34)16-14-28(5)19(20(30)17-25)7-8-22-26(3)11-10-23(32)27(4,18-31)21(26)9-12-29(22,28)6/h7,20-23,31-32H,8-18H2,1-6H3,(H,33,34)/t20-,21+,22+,23-,26-,27-,28+,29+,30-/m0/s1
InChi Key
PGOYMURMZNDHNS-MYPRUECHSA-N
Origin
Plant/Lonicera fulvotomentosa
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-32741-10 |
|---|---|
| Supplier Part Number | 32741-10 |
| UM | UN |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/32741m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | CN |
| ProductLine | CAYM |
| Qty | 10 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 1858276-04-6 |