Cayman 2-Hydroxyanthraquinone; Size- 25 G

Ergosterol peroxide is an oxidized sterol and derivative of ergosterol (Item No. ) that has been found in S. aspratus and has diverse biological activities.^,,,, It is active against the P. falciparum chloroquine-sensitive strain FCA 20/GHA with an IC₅₀ value of 8.2 µM. Ergosterol peroxide (6.25-50 µM) induces apoptosis in LNCaP and DU145 prostate cancer cells. It inhibits growth of SNU-1 gastric, SNU-354 hepatoma, and SNU-C4 colorectal cancer cells (IC₅₀s = 18.7, 158.2, and 84.6 µM, respectively). Ergosterol peroxide (60 µM) inhibits LPS-induced NF-kB DNA-binding activity and production of TNF-α in RAW 264.7 cells. Topical application of ergosterol peroxide reduces ear edema in a mouse model of inflammation induced by phorbol 12-myristate 13-acetate (TPA; Item No. ) with an ID₅₀ value of 0.2 mg/ear.

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