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Cayman Deferitrin; 5 Mg; 239101-33-8; ≥98%
NETA PART: | CAYM-33328-5 |
MFG.PART: | 33328-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Agnuside is an iridoid glycoside originally isolated from V. rotundifolia fruit that has diverse biological activities.,,, It inhibits COX-2 with an IC50 value of 0.026 mg/ml but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5, 25, and 100 μM, respectively. Agnuside (0.1-10 μM) induces proliferation of MCF-7 breast cancer cells, an effect that is inhibited by the estrogen receptor antagonist fulvestrant (ICI 182780; Item No. ). In vivo, agnuside (50 mg/kg) reduces acetic acid-induced writhing in mice indicating analgesia. It also suppresses production of the pro-inflammatory mediators prostaglandin E2 (PGE2) and leukotriene B4 (LTB4; Item No. ) and the T cell-mediated cytokines IL-2, TNF-α, INF-γ, IL-4, IL-10, and IL-17 in splenocytes and arthritic paw tissue from arthritic adrenalectomized rats.
WARNING This product is not for human or veterinary use.
Technical Information
- :
- DMF: 10 mg/ml
- DMSO: 10 mg/ml
- Ethanol: 0.5 mg/ml
- PBS (pH 7.2): 0.2 mg/ml
Shipping & Storage Information
SKU | CAYM-33328-5 |
---|---|
Supplier Part Number | 33328-5 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 239101-33-8 |