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Cayman Perhydrofarnesyl Acetone, 100mg
Cayman Perhydrofarnesyl Acetone, 100mg - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$341.00
Your Price
$341.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CAYM-33825-100 |
MFG.PART: | 33825-100 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
(+)-JQ1 (Item No. ) binds to the acetyl-lysine recognition pocket of bromodomains 1 and 2 on BRD4 with Kd values of ~50 and 90 nM, respectively. This displaces BRD4 from nuclear chromatin in cells, inducing differentiation and growth arrest in midline carcinoma cells. CPI-203 is a primary amide analog of (+)-JQ1 which has shown superior bioavailability with oral or i.p. administration. It is comparable or superior to (+)-JQ1 in inhibiting BRD4 binding and action in vitro or in cells., CPI-203 arrests the growth of leukemic T cells in vitro (EC50 = 91 nM) and rapidly suppresses leukemia burden in mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(6S)-4-(4- chlorophenyl)- 2,3,9- trimethyl-6H- thieno[3,2-f] [1,2,4] triazolo [4,3-a][1,4] diazepine-6- acetamide
CAS Number
1446144-04-2
Molecular Formula
C19H18ClN5OS
Formula Weight
399.9
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml
- DMSO: 25 mg/ml
- Ethanol: 20 mg/ml
λmax
255 nm
SMILES
ClC1=CC=C(C=C1)C2=N[C@@H](CC(N)=O)C3=NN=C(C)N3C4=C2C(C)=C(C)S4
InChi Code
InChI=1S/C19H18ClN5OS/c1-9-10(2)27-19-16(9)17(12-4-6-13(20)7-5-12)22-14(8-15(21)26)18-24-23-11(3)25(18)19/h4-7,14H,8H2,1-3H3,(H2,21,26)/t14-/m0/s1
InChi Key
QECMENZMDBOLDR-AWEZNQCLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
SKU | CAYM-33825-100 |
---|---|
Supplier Part Number | 33825-100 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/33825m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 502-69-2 |