Cayman N-(4-Aminobenzoyl)-L-Glutamic Acid (Hydrate); Size- 10 G

Loratadine-d₄ is intended for use as an internal standard for the quantification of loratadine (Item No. ) by GC- or LC-MS. Loratadine is a non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H₁ receptors (K_i = 35 nM).^,, It has been shown to inhibit the release of leukotriene C₄ (IC₅₀ = 8 µM) and histamine (IC₅₀ = 11 µM) from rodent mast cells and to inhibit allergic bronchospasm in guinea pigs with an ED₅₀ value of 0.40 mg/kg. Formulations containing loratadine have been used in the treatment of allergic rhinitis and chronic idiopathic urticaria.

WARNING This product is not for human or veterinary use.