We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman Bcl-2 (Human, Recombinant), Size100 Μg, Purity≥90% E
NETA PART: | CAYM-33984-100 |
MFG.PART: | 33984-100 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Bcl-2 is an anti-apoptotic protein and the founding member of the Bcl-2 family of proteins.1,2 Bcl-2 is composed of a C-terminal helix that acts as a membrane anchor and four highly conserved Bcl-2 homology (BH) domains.1 The BH1, BH2, and BH3 domains form a hydrophobic cleft that mediates protein-protein interactions with the pro-apoptotic proteins Bax and Bak, resulting in their inhibition, whereas the BH4 domain regulates intracellular calcium levels by interacting with the inositol-1,4,5-triphosphate receptor (IP3R) and ryanodine receptors (RyRs).3,1,4 Bcl-2 is highly expressed during embryogenesis and neuron and lymphocyte development and is primarily localized to the mitochondrial outer membrane.5 It inhibits the intrinsic apoptotic pathway by inhibiting Bax- or Bak-induced pore formation in the outer mitochondrial membrane, maintaining the mitochondrial membrane potential, and preventing the release of cytochrome c into the cytosol and the induction of apoptosis.2,3 Bcl-2 has oncogenic function, promoting tumor progression and angiogenesis, as well as metastasis.4 The Bcl2 t(14;18)(q32;q21) translocation results in Bcl-2 overexpression and is a hallmark of follicular lymphoma.6 Bcl-2 is also overexpressed in several other cancers, including chronic lymphocytic leukemia (CLL), diffuse large B cell lymphoma (DLBCL), and prostate cancer.3 Caymans Bcl-2 (human, recombinant) protein can be used for binding assays. This protein consists of 221 amino acids and has a calculated molecular weight of 24.7 kDa.
WARNING This product is not for human or veterinary use.
Technical Information
- BCL2
Shipping & Storage Information
SKU | CAYM-33984-100 |
---|---|
Supplier Part Number | 33984-100 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
Temperature | -80 |
Refrigerated-Frozen | Frozen |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |