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Cayman Atn-161 (Trifluoroacetate Salt), 1mg
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NETA PART: | CAYM-34056-1 |
MFG.PART: | 34056-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
ATN-161 is a peptide derived from fibronectin and an integrin αVβ3 and αVβ5 antagonist.1 It binds to αVβ3 and αVβ5 receptors (Kds = 0.69 and 1 µM, respectively) in MDA-MB-231 breast cancer cells, as well as inhibits the interaction between αVβ5 and human angiotensin-converting enzyme 2 (ACE2) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein in a concentration-dependent manner in cell-free assays.1,2 ATN-161 reduces viral titers in Vero E6 cells infected with SARS-CoV-2 (EC50 = 3.16 µM).2 It inhibits VEGF-induced migration and capillary tube formation of primary human choroidal endothelial cells when used at a concentration of 0.1 µM.3 ATN-161 (1 mg/kg) reduces tumor growth and metastasis in an MDA-MB-231 mouse xenograft model and infarct volume and edema in a mouse model of ischemic stroke induced by middle cerebral artery occlusion (MCAO).1,4
WARNING This product is not for human or veterinary use.
Technical Information
- Ac-PHSCN-NH2
- PHSCN Peptide
- PBS (pH 7.2): 1 mg/ml
Shipping & Storage Information
SKU | CAYM-34056-1 |
---|---|
Supplier Part Number | 34056-1 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/34056m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 904763-27-5 |