Cayman 2-Hydroxy Estrone; Qty- 1; Size-1 Mg

Product Description

Genz-644282 is a topoisomerase I (TOP-I) inhibitor that inhibits TOP-I-mediated DNA cleavage 10-fold more potently than the TOP-I inhibitor topotecan (Item No. ). It inhibits the growth of and is cytotoxic to human and mouse bone marrow cells in a colony-forming unit assay (IC₅₀s = 0.4 and 2.3 nM, respectively; IC₉₀s = 1.2 and 8.4 nM, respectively). It also inhibits the growth of and is cytotoxic to human tumor cell lines (IC₅₀s = 0.15-2 nM; IC₉₀s = 0.7-8.3 nM). Genz-644282 inhibits tumor growth in mouse xenograft models when administered at doses ranging from 1.36 to 2.7 mg/kg.

WARNING This product is not for human or veterinary use.

Technical Information