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Cayman Adl 08-0011 (Hydrochloride); Qty- 1; Size-1 Mg
NETA PART: | CAYM-34298-1 |
MFG.PART: | 34298-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
SR 27897 is a nonpeptide cholecystokinin (CCK) receptor antagonist. It selectively binds to CCK1 receptors in rat pancreatic membranes (IC50 = 0.58 nM) over CCK2 receptors in guinea pig cortical membranes and gastrin receptors in guinea pig gastric gland suspensions (IC50s = 489 and 2,883 nM, respectively). SR 27897 inhibits amylase secretion induced by CCK in isolated rat pancreatic acini (pA2 = 7.50) and CCK-induced guinea pig gallbladder contractions ex vivo (pA2 = 9.57). It completely reverses CCK-induced amylase secretion in rats when administered at a dose of 1 mg/kg. SR 27897 also inhibits CCK-induced gastric and gallbladder emptying in mice (ED50s = 3 and 72 μg/kg, respectively). SR 27897 inhibits gallbladder emptying in a mouse model of egg yolk-stimulated endogenous CCK release (ED50 = 27 μg/kg).
WARNING This product is not for human or veterinary use.
Technical Information
- Lintitript
- DMSO: soluble
Shipping & Storage Information
SKU | CAYM-34298-1 |
---|---|
Supplier Part Number | 34298-1 |
UM | UN |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/34298m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CA |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 170098-43-8 |