Cayman 11-Oxo Etiocholanolone, 5mg

Glycogen synthase kinase 3β (GSK3β) was originally identified for its ability to constitutively phosphorylate and inactivate glycogen synthase, preventing glycogen synthesis. It can also phosphorylate proteins that are relevant to osteogenesis and Alzheimer’s disease, the latter for which it has earned the moniker, tau phosphorylating kinase.^,, AZD 2858 is a pyrazine analog that inhibits GSK3β with a K_i value of 4.9 nM. It crosses the blood brain barrier and inhibits tau phosphorylation in vitro with an IC₅₀ value of 76 nM. AZD 2858 has also been shown to increase bone mass (via Wnt activation) in rats after a two-week treatment with a maximum effective oral dose of 20 mg/kg once daily. Furthermore, by inhibiting GSK3β, AZD 2858 can stabilize β-catenin in rat mesenchymal stem cells (EC₅₀ = 234 nM), spurring osteoblast differentiation.

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