Cayman Gap 27 (Trifluoroacetate Salt), 5mg

Quinidine-d₃ is intended for use as an internal standard for the quantification of quinidine (Item No. ) by GC- or LC-MS. Quinidine is a stereoisomer of the antimalarial agent quinine (Item No. ) and a class Ia antiarrhythmic agent.^, Quinidine blocks the voltage-gated sodium (Na_v) channel Na_v1.5 in a use-dependent manner. It decreases the amplitude and duration of action potentials in isolated canine ventricular myocytes. Quinidine inhibits K_Kr, peak I_Na, and late I_Na (IC₅₀s = 4.5, 11, and 12 µM, respectively) and can induce torsade de pointes in isolated rabbit hearts when used at a concentration of 1 µM. It induces QT prolongation in dogs. Quinidine also binds to M₂ muscarinic acetylcholine receptors (K_i = 7.5 µM for human recombinant receptors expressed in HM2-B10 cells). Formulations containing quinidine have been used in the treatment of atrial fibrillation and ventricular arrhythmias.

WARNING This product is not for human or veterinary use.