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Cayman Ranitidine S-Oxide
NETA PART: | CAYM-35412-5 |
MFG.PART: | 35412-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
S 14506 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A.,,, It selectively binds 5-HT1A over 5-HT1B, 5-HT1C, 5-HT2, and 5-HT3 receptors (Kis = 0.98, 281.8, 31.6, 229, and >1,000 nM, respectively) but also binds the dopamine D2 receptor (Ki = 4.57 nM) in radioligand binding assays., S 14506 stimulates GTPase activity in HEK293 cell membranes expressing 5-HT1A-Gαi1 or 5-HT1A-Gαo1 fusion proteins in a concentration-dependent manner. It reduces immobility time in the forced swim test in rats with a minimum effective dose (MED) of 0.01 mg/kg. S 14506 (0.0025-0.63 mg/kg) increases punished responding in a pigeon conflict procedure, indicating anxiolytic-like activity.
WARNING This product is not for human or veterinary use.
Technical Information
- DMSO: soluble
- Ethanol: soluble
Shipping & Storage Information
SKU | CAYM-35412-5 |
---|---|
Supplier Part Number | 35412-5 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/35412m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CA |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 73851-70-4 |