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Cayman N-Hydroxylamine Dapsone; 5 Mg; 32695-27-5; ≥98%
NETA PART: | CAYM-35446-5 |
MFG.PART: | 35446-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
N-hydroxylamine Dapsone is an active metabolite of dapsone (Item No. 23743).1 It is formed via N-hydroxylation of dapsone by the cytochrome P450 (CYP) isoforms CYP2C8, CYP2C9, CYP2C18, and CYP2C19 in the liver.2 N-hydroxylamine Dapsone is cytotoxic to rat hepatocytes (LC50 = 3.6 mM).3 It induces hemolysis in isolated human erythrocytes at a concentration of 100 µM.1 N-hydroxylamine Dapsone induces phosphatidylserine (PS) exposure on the outer membrane, a marker of apoptosis and platelet activation, and increases the production of reactive oxygen species (ROS) in a concentration-dependent manner in isolated human erythrocytes. It increases thrombus weight in a rat model of surgically induced thrombosis when administered at a single dose of 50 mg/kg or at a dose of 10 mg/kg per day for four days.
WARNING This product is not for human or veterinary use.
Technical Information
- Dapsone hydroxylamine
- DDS-NHOH
- DMSO: soluble
Shipping & Storage Information
SKU | CAYM-35446-5 |
---|---|
Supplier Part Number | 35446-5 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 32695-27-5 |