Cayman 4-Methoxy Estrone

2-PMAP is an inhibitor of the production of amyloid precursor protein (APP) and amyloid-β (Aβ) secretion. It reduces levels of APP and its intracellular C-terminal fragments α-CTF and β-CTF in CHO APP751SW cells when used at a concentration of 10 μM. 2-PMAP also reduces secretion of Aβ (1-40) and Aβ (1-42) by 88.6 and 84.9%, respectively, in CHO APP751SW cells when used at a concentration of 50 μM without inducing cellular toxicity. In vivo, 2-PMAP reduces brain levels of full-length APP, α-CTF and β-CTF, and soluble Aβ (1-40) and Aβ (1-42) in the APP_SWPS1_dE9 transgenic mouse model of Alzheimers disease. It also improves novel object memory as well as spatial memory in the radial arm maze in APP_SWPS1_dE9 transgenic mice.

WARNING This product is not for human or veterinary use.