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Cayman Angiotensin A (Trifluoroacetate Salt); 25 Mg; ≥98%
NETA PART: | CAYM-36063-25 |
MFG.PART: | 36063-25 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Angiotensin A is an angiotensin II type 1 (AT1) and AT2 receptor agonist and active metabolite of the peptide hormone angiotensin II (Item No. 17150).1 It is formed from angiotensin II via decarboxylation of the N-terminal aspartate residue. Angiotensin A binds to AT1 and AT2 receptors in HEK293 cells expressing the rat receptors (IC50s = 0.29 and 0.12 nM, respectively, in radioligand binding assays) and induces calcium mobilization in vascular smooth muscle cells (VSMCs; EC50 = 100 nM). It increases the perfusion pressure in isolated perfused rat kidney (EC50 = 443 nM), an effect that can be reversed by the AT1 antagonist EXP-3174 (losartan carboxylic acid; Item No. 15957). The ratio of angiotensin A to angiotensin II (Ang A/Ang II) in the plasma is increased in patients with end-stage renal failure and serum levels of angiotensin A are decreased in patients with pulmonary arterial hypertension.1,2
WARNING This product is not for human or veterinary use.
Technical Information
- Ala-Arg-Val-Tyr-Ile-His-Pro-Phe
- Des[Asp1]-[Ala1]-Ang II
- DMSO: 5 mg/ml
- PBS (pH 7.2): 5 mg/ml
Shipping & Storage Information
SKU | CAYM-36063-25 |
---|---|
Supplier Part Number | 36063-25 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
ProductLine | CAYM |
Qty | 25 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |