Cayman Flavokawain A

Citrullination and carbamylation are two post-translational modifications that result in the generation of citrulline and homocitrulline, two highly related, non-standard amino acids. While citrullination of arginine is catalyzed by peptidylarginine deiminases (PADs), homocitrulline results from the non-enzymic reaction of cyanate with lysine. Carbamylation occurs at low levels in healthy individuals, but at higher levels in several clinical conditions such as atherosclerosis, kidney disease, and inflammation.^,, Carbamylation can lead to changes in protein function, cellular function, and generation of an immune response to homocitrulline containing proteins.^,, This product contains carbamylated human fibrinogen (α, β and γ chains).

WARNING This product is not for human or veterinary use.