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Cayman Flavokawain A
Cayman Flavokawain A - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$466.00
Your Price
$466.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-36083-50 |
| MFG.PART: | 36083-50 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Flavokawain A is a chalcone that has been found in P. methysticum and has diverse biological activities.1,2,3 It activates nuclear factor erythroid 2-related factor 2 (Nrf2) and heat shock factor 1 (Hsf1; EC50s = 14.1 and 7.9 µM, respectively, in reporter assays), increases glutathione (GSH) levels, and protects against hydrogen peroxide-induced cytotoxicity in HepG2 cells.1 Flavokawain A (10 and 20 µM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS), COX-2, nitric oxide (NO), and prostaglandin E2 (PGE2; Item No. 14010) levels in RAW 264.7 macrophages.2 It induces apoptosis in T24 bladder cancer cells when used at a concentration of 12.5 µg/ml.3 Flavokawain A (50 mg/kg) reduces tumor growth in an EJ bladder cancer mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2E)-1-(2-
CAS Number
37951-13-6
Synonyms
- Flavokavain A
- 4-methoxy Flavokawain B
Molecular Formula
C18H18O5
Formula Weight
314.3
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 5 mg/ml
- DMSO: 2 mg/ml
λmax
361 nm
SMILES
COC1=C(C(O)=CC(OC)=C1)C(/C=C/C2=CC=C(C=C2)OC)=O
InChi Code
InChI=1S/C18H18O5/c1-21-13-7-4-12(5-8-13)6-9-15(19)18-16(20)10-14(22-2)11-17(18)23-3/h4-11,20H,1-3H3/b9-6+
InChi Key
CGIBCVBDFUTMPT-RMKNXTFCSA-N
Origin
Plant/Piper methysticum
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-36083-50 |
|---|---|
| Supplier Part Number | 36083-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/36083m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | CN |
| ProductLine | CAYM |
| Qty | 50 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 37951-13-6 |