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Cayman Bc-1618
NETA PART: | CAYM-36136-1 |
MFG.PART: | 36136-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
BC-1618 is an inhibitor of F-box only protein 48 (FBXO48), an E3 ubiquitin ligase.1 It is selective for FBXO48 over FBXO30 at 3 µM. BC-1618 (0.5-10 µM) increases the levels of phosphorylated AMP-activated protein kinase (pAMPK) and phosphorylated acetyl-CoA carboxylase (pACC), an AMPK downstream substrate, in HEK293T cells expressing human FBXO48. It induces mitochondrial fission in BEAS-2B cells and autophagy in HEK293A cells expressing GFP-tagged LC3. BC-1618 also inhibits LPS-induced activation of NF-κB in THP-1 cells in a reporter assay and cytokine release in isolated human peripheral blood mononuclear cells (PBMCs). It increases insulin sensitivity in a mouse model of high-fat diet-induced obesity when administered at a dose of 20 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
- DMSO: soluble
Shipping & Storage Information
SKU | CAYM-36136-1 |
---|---|
Supplier Part Number | 36136-1 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/36136m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 2222094-18-8 |