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Cayman K 41498 (trifluoroacetate salt)
Cayman K 41498 (trifluoroacetate salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$289.00
Your Price
$289.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CAYM-36417-1 |
MFG.PART: | 36417-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
K 41498 is a peptide antagonist of corticotropin-releasing factor receptor 2α (CRF2α) and CRF2β (Kis = 0.66 and 0.62 nM, respectively, in HEK293 cells expressing the human receptors).1 It is selective for CRF2α and CRF2β over CRF1 (Ki = 425 nM in HEK293 cells expressing the human receptor). K 41498 (1.84 µg/animal, i.v.) prevents hypotension induced by urocortin (Item No. 24745) in rats. Intrathecal administration of K 41498 (0.075-0.5 µmol/animal) decreases the mechanical paw withdrawal threshold in a rat model of nociception induced by complete Freunds adjuvant.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
D-phenyl alanyl-L- histidyl-L- leucyl-L- leucyl-L- arginyl-L- lysyl-L- norleucyl-L- isoleucyl-L-α- glutamyl-L- isoleucyl-L-α- glutamyl-L- lysyl-L- glutaminyl-L- α-glutamyl-L- lysyl-L-α- glutamyl-L- lysyl-L- glutaminyl-L- glutaminyl-L- alanyl-L- alanyl-L- asparaginyl-L- asparaginyl-L- arginyl-L- leucyl-L- leucyl-L- leucyl-L-α- aspartyl-L- threonyl-L- isoleucin amide, trifluoro acetate salt
Molecular Formula
C162H276N48O46 • XCF3COOH
Formula Weight
3632.2
Purity
≥95%
Formulation(Request formulation change)
A solid
Peptide Sequence
FHLLRKXIEIEKQEKEKQQAANNRLLLDTI-NH2
Solubility(Learn about Variance in Solubility)
- Water: Soluble
SMILES
O=C([C@@H](CC1=CC=CC=C1)N[H])N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CCCC)C(N[C@@]([H])([C@H](CC)C)C(N[C@H](C(N[C@@]([H])([C@H](CC)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@]([H])(C(N[C@@]([H])([C@H](CC)C)C(N)=O)=O)[C@@H](C)O)=O)CC(O)=O)=O)=O)=O)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CC(N)=O)=O)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)CCCCN[H])=O)CCC(O)=O)=O)CCCCN[H])=O)CCC(O)=O)=O)CCC(N)=O)=O)CCCCN[H])=O)CCC(O)=O)=O)=O)CCC(O)=O)=O)=O)=O)CCCCN[H])=O)CCCNC(N)=N)=O)=O)=O)CC2=CNC=N2.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C162H276N48O46.C2HF3O2/c1-21-25-41-94(184-136(232)95(42-29-33-62-163)185-140(236)99(46-37-66-179-161(174)175)189-149(245)108(68-80(5)6)201-152(248)111(71-83(11)12)204-154(250)113(74-92-78-178-79-181-92)199-134(230)93(167)73-91-39-27-26-28-40-91)147(243)208-128(86(16)23-3)159(255)197-107(54-61-125(223)224)148(244)209-129(87(17)24-4)158(254)196-106(53-60-124(221)222)146(242)188-97(44-31-35-64-165)138(234)193-103(50-57-119(170)214)143(239)195-105(52-59-123(219)220)145(241)187-98(45-32-36-65-166)139(235)194-104(51-58-122(217)218)144(240)186-96(43-30-34-63-164)137(233)192-102(49-56-118(169)213)142(238)191-101(48-55-117(168)212)135(231)183-88(18)132(228)182-89(19)133(229)198-114(75-120(171)215)156(252)205-115(76-121(172)216)155(251)190-100(47-38-67-180-162(176)177)141(237)200-109(69-81(7)8)150(246)202-110(70-82(9)10)151(247)203-112(72-84(13)14)153(249)206-116(77-126(225)226)157(253)210-130(90(20)211)160(256)207-127(131(173)227)85(15)22-2;3-2(4,5)1(6)7/h26-28,39-40,78-90,93-116,127-130,211H,21-25,29-38,41-77,163-167H2,1-20H3,(H2,168,212)(H2,169,213)(H2,170,214)(H2,171,215)(H2,172,216)(H2,173,227)(H,178,181)(H,182,228)(H,183,231)(H,184,232)(H,185,236)(H,186,240)(H,187,241)(H,188,242)(H,189,245)(H,190,251)(H,191,238)(H,192,233)(H,193,234)(H,194,235)(H,195,239)(H,196,254)(H,197,255)(H,198,229)(H,199,230)(H,200,237)(H,201,248)(H,202,246)(H,203,247)(H,204,250)(H,205,252)(H,206,249)(H,207,256)(H,208,243)(H,209,244)(H,210,253)(H,217,218)(H,219,220)(H,221,222)(H,223,224)(H,225,226)(H4,174,175,179)(H4,176,177,180);(H,6,7)/t85-,86-,87-,88-,89-,90+,93+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,127-,128-,129-,130-;/m0./s1
InChi Key
KDCMDFVMLNEQBZ-PVYGMQBSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
SKU | CAYM-36417-1 |
---|---|
Supplier Part Number | 36417-1 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |