Cayman 3-Hydroxyphenylacetic Acid

3-Hydroxyphenylacetic acid is a phenolic acid with diverse biological activities.^1,2,3,4 It is formed via microbial metabolism of polyphenolic compounds, including the flavonoid quercetin (Item No. 10005169), by gut microbiota.⁵ 3-Hydroxyphenylacetic acid binds to the γ-hydroxybutyrate receptor (GHBR; IC₅₀ = 12 µM) and GABA_A receptors in rat cerebrocortical membranes.¹ It increases the activity of aldehyde dehydrogenase (ALDH) in Hepa-1c1c7 and HepG2 cells and protects Hepa-1c1c7 cells from acetaldehyde-induced cytotoxicity when used at a concentration of 10 µM.² 3-Hydroxyphenylacetic acid is active against P. aeruginosa (MIC = 2.1 mg/ml).³ It induces ataxia and decreases locomotor activity in mice (ED₅₀s = 1,677.3 and 1,441.3 mg/kg, respectively), as well as decreases systolic and diastolic blood pressure in spontaneously hypertensive rats when administered at doses ranging from 0.1 to 10 mg/kg.^1,4

WARNING This product is not for human or veterinary use.