Cayman Pf-04753299

PF-04753299 is an inhibitor of LpxC (IC₅₀ = 1.37 nM), a bacterial deacetylase involved in the biosynthesis of LPS lipid A.¹ It is selective for LpxC over a panel of 16 human matrix metalloproteinases (MMPs; K_is = >1 µM for all). PF-04753299 is active against P. aeruginosa, K. pneumoniae, E. coli, E. aerogenes, C. freundii, and A. baumannii (MIC₉₀s = 4, 16, 2, 4, 8, and 32 µg/ml, respectively). In vivo, PF-04753299 reduces splenic bacterial burden in a mouse model of systemic P. aeruginosa infection (ED₅₀ = 35 mg/kg).

WARNING This product is not for human or veterinary use.