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Cayman Ly345899
Cayman Ly345899 - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$276.00
Your Price
$276.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-36627-10 |
| MFG.PART: | 36627-10 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
AMG 517 is an antagonist of transient receptor potential vanilloid 1 (TRPV1; IC50 = 0.9 nM). It inhibits mechanical and thermal allodynia in a rat model of burn injury when administered intrathecally at a dose of 165 µg. AMG 517 (150 and 300 µg/kg) also reverses increases in the level of calcitonin gene-related peptide (CGRP) and increases expression of GFAP and GAP-43 in the dorsal horn of the spinal cord, as well as enhances axonal regeneration in a rat model of sciatic nerve transection injury.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[4-[[6-[4-
CAS Number
659730-32-2
Molecular Formula
C20H13F3N4O2S
Formula Weight
430.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 112.5 mg/ml
- DMSO: 14.3 mg/ml
- Ethanol: 3.3 mg/ml
λmax
247, 272 nm
SMILES
O=C(C)NC1=NC2=C(S1)C=CC=C2OC3=NC=NC(C4=CC=C(C(F)(F)F)C=C4)=C3
InChi Code
InChI=1S/C20H13F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-10H,1H3,(H,26,27,28)
InChi Key
YUTIXVXZQIQWGY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-36627-10 |
|---|---|
| Supplier Part Number | 36627-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/36627m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | CN |
| ProductLine | CAYM |
| Qty | 10 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 10538-99-5 |